Primary vs. Secondary Adrenal Insufficiency. What’s the Difference?

Adrenal insufficiency can be classified into two types: primary and secondary. Understanding the differences between these two forms is key for effective diagnosis and treatment. 

Adrenal Insufficiency: Rare but Devastating

Adrenal insufficiency arises when the adrenal glands do not produce sufficient amounts of essential hormones. These glands, located atop the kidneys, play a key role in producing cortisol and aldosterone.

BrigHTN: Baxdrostat for Resistant Hypertension

Inhibiting aldosterone synthase presents a promising approach to treating hypertension. However, it is key to ensure selective inhibition to avoid compromising cortisol production. Recently, researchers have identified Baxdrostat as a highly selective AS inhibitor that does not interfere with cortisol synthesis. The specificity of Baxdrostat in inhibiting aldosterone synthase over cortisol synthase is 100:1