A serious article analyzing the prevalence of left-sided vs. right-sided adrenal tumors. Prior observations have consistently shown that left-sided adenomas are more common than right-sided ones, in 2:1 ratio.

Although a reason could be embryological, leading to a greater left adrenal vascularity, innervation, volume and mass; authors suggest that asymmetry could also be due to anatomical locations of the glands.

The left adrenal gland is surrounded by the hypo-attenuated visceral fat, making it easier to be seen by imaging, versus the right gland which is somewhat compressed by the relatively hyper-attenuated liver and kidney.

Authors’ argument is compelling enough that clinicians should be aware of possibly missing right-sided adrenal tumors, especially in the context of hyper-functionality; elevated catecholamines, cortisol, aldosterone and DHEAs.

Also see:

JOURNAL OF THE ENDOCRINE SOCIETY

CROSS-SECTIONAL

March 2018

Context

It is presumed that the incidence of adrenal adenomas is symmetric between the left and right adrenal gland; however, anecdotal observations suggest a potential lateralizing asymmetry.

Objective

To investigate the symmetry in detection of adrenal adenomas and relevance to patient care.

Design: Cross-sectional and longitudinal studies. 1376 patients with abdominal computed tomography or magnetic resonance imaging demonstrating benign-appearing adrenal adenomas.

Main Outcome: Location and size of adrenal adenomas.

Results

Left-sided adenomas were discovered in 65% of patients, right-sided in 21%, and bilateral adenomas in 14%.

Among UNILATERAL adenomas, 75% were left-sided. Left-sided adenomas were more prevalent than right-sided adenomas in each size category except the largest:

The LEFT adrenal gland is surrounded by a layer of hypoattenuating retroperitoneal fat and is located above the left kidney without compression from surrounding structures, thus allowing for better visualization on abdominal cross-sectional imaging.
In contrast, the RIGHT adrenal gland has less surrounding retroperitoneal fat, abuts the liver, and lies between the liver and kidney, which may obscure recognition of small abnormalities. Indeed, the right adrenal gland is often compressed in a manner such that the lateral limbs are indistinguishable from one another.
The proposition of an imaging detection bias favoring the left adrenal gland is further supported by the observation that left-sided adrenal adenomas were detected despite being significantly smaller than those on the right, particularly for adrenal adenomas in smaller size ranges. As the size of the adenomas increased, the ability to detect both left-sided and right-sided adenomas appeared to equilibrate.

This prompted our attempt to investigate whether BMI, as a crude proxy of visceral adiposity and periadrenal adipose tissue, influenced the detection asymmetry. We observed only a mild and nonsignificant trend suggesting that patients with higher BMI (or greater adiposity) may have less asymmetry in the detection of adrenal adenomas; however, BMI is not an accurate measure of abdominal adiposity, and further studies using quantification of visceral and periadrenal adipose tissue would be required to better test this hypothesis.

Alternatively, another hypothesis for the lateralizing asymmetry we observed could involve a fundamental predisposition for left-sided adrenal neoplasia. There have been prior studies that have suggested asymmetry in the detection of malignancies of the breast; however, to our knowledge, there is limited evidence to support a predisposition for asymmetric adrenal neoplasia.

One of the earliest studies to note a lateralizing asymmetry of adrenal adenomas was an autopsy series published by Russi et al. in 1945 that noted that among 68 unilateral adrenal adenomas, 34 (50%) were found on the left adrenal, 21 (31%) were found on the right adrenal, and 13 (19%) were found on bilateral adrenal glands.

One potential explanation for this asymmetry may include potential morphologic differences between the left and right adrenal glands. In one autopsy study in 2001, Lam et al. examined the adrenal glands of 333 patients and found a significantly greater dimension and mean weight of the left adrenal gland compared with the right. Similarly, multiple fetal adrenal development studies have found an asymmetry in the development of the adrenal glands such as greater mass, volume, thickness, and surface area of the left adrenal gland compared with the right adrenal gland during gestation.

A study by Aliab’ev and Paderov on the adrenal glands of 161 men of different ages also found an asymmetry marked by greater mass of the left adrenal and its cortex over the right and that the increasing adrenal mass with age was predominantly due to the growth of cortex in the left adrenal.

Adult adrenal volumetric studies have reported conflicting results on whether there exists a significant difference between the left and right mean adrenal volume. In an analysis of 154 patients, Carsin-Vu et al. found that the mean volume of left adrenal gland (4.5 ± 1.6cm3) was significantly greater than the mean volume of the right adrenal gland (3.8 ± 1.3cm3).

Similarly, in a study of 105 patients, Schneller et al. found a significantly greater left adrenal mean volume (4.84 ± 1.67cm3 vs right 3.62 ± 1.23 cm3) and left adrenal total width (18.96 ± 3.37 mm vs right 15.80 ± 3.05 mm).

However, studies with smaller sample sizes of 40 patients by Nougaret et al. and 81 patients by Wang et al. failed to demonstrate any significant difference between the left and right adrenal gland volume.

IF the left adrenal gland is indeed larger in dimension and greater in volume, then it may be possible that greater tissue mass in the left adrenal may potentially lead to greater opportunities for neoplastic transformation. It may also be possible that the greater left adrenal volume and size could lead to better visualization of any abnormalities.

In addition to differences in morphology, other differences such as innervation, vascular supply, and venous drainage may also play a role in the higher frequency of adenomas observed in the left adrenal gland. Tóth et al. conducted a study using viral transneuronal tracing techniques that demonstrated an asymmetry with greater supraspinal innervation of the left adrenal gland compared with the right adrenal gland in rodents. Furthermore, although it is recognized that adrenal venous drainage is asymmetric, studies have also demonstrated asymmetry in vascular supply with an additional group of posterior arteries supplying the posterior surface of left adrenal gland in some individuals.

These differences in vascular supply and drainage as well as innervation may further contribute to differences in size and susceptibility to neoplasia.

The findings of this study have several important clinical implications. Our data suggest that in the current era of frequent adrenal incidental findings:

(1) there is a substantial detection bias toward identifying left-sided adrenal adenomas;

(2) the detection of right-sided adrenal adenomas may be delayed until they are significantly larger, thus resulting in a window of time where recommended biochemical screening and surveillance are not conducted and exposure to autonomous adrenal hormone secretion may go unrecognized; and

(3) the ability to detect bilateral adrenal diseases may be unreliable, particularly when only a left-sided adrenal abnormality is seen in conditions such as primary aldosteronism and adrenal Cushing syndrome.

For example, in a prior study by Young et al., when treatment of primary aldosteronism relied on CT findings alone, 25% of patients would have had unnecessary or inappropriate unilateral adrenalectomy due to incorrect identification of the responsible adrenal gland or failure to detect bilateral disease. Similarly, Kempers et al. conducted a systematic review of 950 patients that demonstrated that CT/MRI failed to identify bilateral disease in 14.6% of patients and identified the wrong adrenal gland in 3.9% of patients.

An alternative viewpoint is that this detection bias may result in “overevaluation” of patients with left-sided adrenal adenomas. In other words, the superior ability to recognize left-sided adenomas may result in more biochemical evaluations and resultant medical or surgical interventions for those with left-sided adenomas when compared with right-sided adenomas.

Indeed, the higher incidence of left-sided adrenalectomies has been reported many times before. Rieder et al. examined consecutive patients receiving laparoscopic adrenalectomy between 1998 and 2007 in Southern California Kaiser Permanente Hospital and reported 109 left-sided adrenalectomies and 54 right-sided adrenalectomies (twice as many left-sided interventions). Similarly, a study from Nancy University Hospital in France documented 64 left-sided and 36 right-sided adrenalectomies from November 2001 to November 2007 in 100 consecutive patients (78% more left-sided interventions).

Our findings must be interpreted within the context of our study design. The main limitations of this study are related to the interpretation of radiographic imaging. Very small adrenal abnormalities (<0.5 cm) sometimes could not be quantified with a reliable size measurement, and we therefore assigned them default size of 1 mm; however, we present our data in both continuous and categorical formats to demonstrate that our observations related to size were consistent.

Furthermore, measurement technique of adrenal adenomas can vary depending on how radiologists manually place measurement bars in their imaging software, and our study relied on radiology interpretations made by many heterogeneous evaluators; however, our findings reflect “real-world” observations and therefore provide a practical representation of what may be encountered in medical practice.

As with all observational studies such as ours, there is a risk of bias in the selection of patients; the patients in the present study did not undergo systematic prospective imaging, rather they were retrospectively selected based on predefined inclusion criteria from a large registry.

Our study focused on nonfunctional and benign-appearing adrenal adenomas to minimize confounding and bias attributed to hormonally active adenomas and adrenal malignancies because they are known to impart higher risk for cardiometabolic disease and are associated with increased frequency of imaging; thus, our results may not be generalizable to individuals with functional or malignant adrenal tumors.

Furthermore, we did not have reliable outcomes assessments of all potential surgical interventions, growth in adenoma sizes, or development of incident hormone excess, because our study design and electronic medical record system was not designed to uniformly capture all future events. Thus, even though we suggest that a potential implication of our findings could be the unreliable biochemical screening and detection of bilateral adrenal diseases, our present study was not designed to specifically evaluate this.

IN CONCLUSION, our findings suggest a strong preferential detection for left-sided vs right-sided adrenal adenomas. Left-sided adenomas are detected at significantly smaller sizes than right-sided adenomas, and patients with bilateral adrenal abnormalities more frequently present with larger left-sided adrenal adenomas. Taken together, these findings may implicate a radiologic detection bias that has important clinical implications.

First, this asymmetric detection could lead to underrecognition of right-sided adrenal adenomas that may delay hormonal screening as well as result in overevaluation and treatment of left-sided adrenal adenomas.

Second, these findings may provide one explanation for why detection of bilateral disease is unreliable on cross-sectional imaging. Clinicians should be aware of this lateralizing detection asymmetry when evaluating abdominal imaging and managing patients with adrenal adenomas.

<1.0 cm, 87%;
1.0 – 2.0 cm, 74%;
2.0 – 3.0 cm, 72%;
≥3.0 mm, 56% (P < 0.0001 for each category, except P = 0.19 when ≥3.0 cm).

Among those with BILATERAL adenomas, the left-sided adenoma was significantly larger than the right one in 61% of patients (P < 0.001).

There were no significant differences in the baseline prevalence or incidence of cardiometabolic diseases between patients with left-sided vs right-sided adenomas during 5.10 (4.2) years of follow-up.

Conclusions

Adrenal adenomas are substantially more likely to be identified on the LEFT adrenal than the right. This observation may be due to detection bias attributed to the location of the right adrenal, which may preclude identification of right-sided adenomas until they are substantially larger. These findings suggest the potential for an underrecognition of right-sided adenomas that may also impair the accurate detection of bilateral adrenal diseases.

More from the publication:

The frequent use of abdominal cross-sectional imaging has resulted in a high incidence of incidentally discovered adrenal tumors. Multiple large studies suggest that the prevalence of incidentally discovered adrenal tumors can range to be as high as 4-10%. Although the vast majority of adrenal tumors represent benign adenomas, even benign adrenal adenomas may secrete excessive adrenal hormones that may contribute to cardiometabolic disease.

It is generally presumed that the detection of adrenal tumors is symmetric, with half the abnormalities detected on the left, and half detected on the right adrenal gland; however, prior studies focused on other objectives included data suggesting a potential lateralizing asymmetry that favored detection of left-sided adrenal tumors.

These previous observations suggest that the left adrenal gland may be more prone to developing adrenal neoplasia, OR, alternatively, that left-sided adrenal tumors may be more readily apparent to radiologists and thus result in a detection bias.

The anatomy and location of the LEFT adrenal gland, with ample periadrenal adipose tissue, allow for easier visualization compared with the RIGHT adrenal gland, which is often compressed between the liver and right kidney.

Therefore, we hypothesized that left-sided adrenal adenomas may be more frequently detected compared with right-sided adrenal adenomas. We speculated that this observation could have important clinical implications: a left-sided preference for detecting adrenal adenomas could result in the underdetection of right-sided adrenal adenomas and unreliable recognition of bilateral adrenal adenomas. Because the prognostication and treatment of adrenal disorders (i.e., primary aldosteronism, adrenal Cushing syndrome) may depend on reliable identification of unilateral vs bilateral disease, any lateralizing bias in recognizing adrenal adenomas could impact the delivery of quality clinical care to patients. In this study, we report the results of a large and dedicated systematic investigation focused on the laterality of adrenal adenoma detection.

It is commonly presumed that the frequency and ability to detect adrenal adenomas is symmetric between the left and the right adrenal glands.

In contrast, our findings suggested a marked threefold greater detection of left-sided unilateral adrenal adenomas compared with the right side.

We observed that left-sided adrenal adenomas were detected more frequently even when smaller in size than right-sided adenomas; alternatively, right-sided adenomas were larger than left-sided adenomas when detected.

Furthermore, when bilateral adrenal adenomas were detected, the left-sided adenoma tended to be larger in size than the right-sided adenoma. Collectively, these findings suggest a potential bias toward the detection of left-sided adrenal adenomas, but perhaps more importantly, a concern that right-sided adrenal adenomas need to be significantly larger than left-sided adenomas before they are detected.

This may have two important implications for patient care:

(1) the recognition of right-sided adrenal adenomas may be delayed until a later stage of progressive growth; and

(2) the underrecognition of right-sided adrenal adenomas may result in a substantial inaccuracy in identifying true bilateral adrenal abnormalities, which may be most relevant for conditions such as primary aldosteronism and adrenal Cushing syndrome where treatment decisions rely on reliable lateralization.

To our knowledge, the present study is the first study dedicated to investigating the asymmetry in detecting adrenal adenomas, and it is the largest study to date with data on this topic. Prior studies by Kim et al., Debono et al., and Sangwaiya et al. all included data that also suggested a potential left-sided asymmetry, but had small study populations and focused on other research objectives. Note that a survey on adrenal incidentalomas by Mantero et al. observed more right-sided adrenal tumors than those on the left side; however, the imaging modality used was predominantly ultrasound, which is not regarded as sensitive as CT or MRI, and is more often performed to evaluate the right-sided abdominal organs. Indeed, when Mantero et al. restricted their analysis to the 247 adrenal adenomas detected by CT imaging alone, the asymmetry was no longer apparent.

Therefore, our findings substantially extend and build upon these prior observations. Our study was not designed to investigate the underlying cause for the asymmetry we observed; however, we suspect that the preferential identification of left-sided adrenal adenomas may be attributable to radiologic detection bias due to the anatomic differences between the left and right adrenal glands.

The LEFT adrenal gland is surrounded by a layer of hypoattenuating retroperitoneal fat and is located above the left kidney without compression from surrounding structures, thus allowing for better visualization on abdominal cross-sectional imaging.
In contrast, the RIGHT adrenal gland has less surrounding retroperitoneal fat, abuts the liver, and lies between the liver and kidney, which may obscure recognition of small abnormalities. Indeed, the right adrenal gland is often compressed in a manner such that the lateral limbs are indistinguishable from one another.
The proposition of an imaging detection bias favoring the left adrenal gland is further supported by the observation that left-sided adrenal adenomas were detected despite being significantly smaller than those on the right, particularly for adrenal adenomas in smaller size ranges. As the size of the adenomas increased, the ability to detect both left-sided and right-sided adenomas appeared to equilibrate.

These differences in vascular supply and drainage as well as innervation may further contribute to differences in size and susceptibility to neoplasia.

The findings of this study have several important clinical implications. Our data suggest that in the current era of frequent adrenal incidental findings:

(1) there is a substantial detection bias toward identifying left-sided adrenal adenomas;