Obstructive sleep apnea in cushing’s syndrome

Cushing’s syndrome is a rare endocrine illness. Although its reported  incidence is about 10 cases per million people each year, it is estimated to be much higher in subclinical scenarios. It can lead to several pathologies such as diabetes, hypertension, high triglycerides, blood clots, osteoporosis, muscle loss and cardiovascular mortality.

The current study adds obstructive sleep apnea as another possible complication of CS, independent of age, gender, body mass index and insulin resistance.

Should patients with obstructive sleep apnea be screened for subclinical cushing’s syndrome?


Cortisol, glucose and blood pressure increase during obstructive sleep apnea

A group of 31 participants with established obstructive sleep apnea were randomized to continue or stop CPAP. Patients were analyzed for several metabolic variables. Untreated individuals experienced higher levels of serum cortisol, glucose and systolic blood pressure among other alterations.

Such anomalies are well known risk factors for development of diabetes, hypertension and cardiovascular illness. It is important to screen, diagnose and treat patients with obstructive sleep apnea. Adherence to therapy needs to be emphasized too.