Homozygous Familial Hypercholesterolemia

Familial hypercholesterolemia is not simply ordinary high cholesterol at a higher level. It causes elevated LDL from childhood, creating decades of additional artery exposure. Dr. Tashko explains how family history, genetic testing, cascade screening, apoB, Lp(a), and cardiovascular imaging fit together. The review also outlines modern treatment with statins, ezetimibe, PCSK9 therapies, bempedoic acid, and specialized care for severe disease and prevention across affected families.