Metabolic Inflammation In The Brain

Central insulin resistance develops when the brain responds weakly to insulin’s signals about appetite, energy balance, metabolism, and memory. It may accompany obesity, prediabetes, type 2 diabetes, fatty liver disease, poor sleep, and metabolic inflammation. Although no routine test can diagnose it, exercise, restorative sleep, thoughtful nutrition, weight management, and appropriate medication can improve the broader metabolic environment that shapes brain insulin signaling over time.